Do PFAS chemicals in clothing affect fertility and IVF success?

Per- and polyfluoroalkyl substances (PFAS), often called forever chemicals, are used in textiles for water resistance, stain proofing, and wrinkle resistance. Research has linked PFAS exposure to reduced fecundability, meaning it takes longer for exposed couples to achieve pregnancy. Studies of women undergoing IVF treatment have found that those with higher blood concentrations of PFAS had lower success rates, with fewer embryos reaching viable development stages.

PFAS compounds are exceptionally persistent in the body, with half-lives measured in years rather than days. They accumulate in blood, liver, and reproductive tissues over a lifetime of exposure. In the reproductive system, PFAS interfere with estrogen and thyroid hormone signaling, both of which are essential for ovulation, implantation, and early pregnancy maintenance. Even low-level chronic exposure from everyday sources like clothing can contribute to a meaningful body burden over time.

For couples investing in fertility treatment, minimizing PFAS exposure from controllable sources makes practical sense. Clothing labeled as water-resistant, stain-proof, or wrinkle-free often contains PFAS treatments. Choosing untreated natural fabrics is the simplest way to avoid this exposure pathway. ONDU's curated brands avoid PFAS finishes entirely, and certifications like OEKO-TEX and GOTS specifically test for these compounds.